Ophiocordin,an antifungal antibiotic of Cordyceps ophioglossoides |
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| Authors: | Helmut Kneifel Wilfried A. Konig Wolfgang Loeffler Renate Müller |
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| Affiliation: | (1) Lehrstuhl Mikrobiologie I, Institut für Biologie II, der Universität Tübingen, Auf der Morgenstelle 28, D-7400 Tübingen 1, Federal Republic of Germany;(2) Present address: Abteilung für Algenforschung und Algentechnologie, Gesellschaft für Strahlen-und Umweltforschung, Bunsen-Kirchhoff-Str. 13, D-4600 Dortmund, Federal Republic of Germany;(3) Present address: Institut für Organische Chemie und Biochemie, Universität Hamburg, Martin-Luther-King-Platz 6, D-2000 Hamburg 13, Federal Republic of Germany;(4) Present address: Lenrstuhl für Mikrobiologie der Technischen Universität, Schneiderberg 50, D-3000 Hannover, Federal Republic of Germany |
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| Abstract: | An unknown antibiotic, ophiocordin, C21H22N2O8, MW: 430, was isolated from submerged cultures of Cordyceps ophioglossoides, strain TÜ 276, grown in a glycerol soybean meal medium at 27°C. The antibiotic was extracted from acidified culture fluids with n-butanol and purified by subsequent column chromatography on DEAE-Sephadex and cellulose. Studies including nuclear magnetic resonance and mass spectrometry resulted in proposals of partial structures of the molecule. Inhibition by ophiocordin could be demonstrated for a small number of fungi belonging to different taxonomic groups. Bacteria were not inhibited. The antifungal effect was antagonized by ammonia and nitrate ions and by certain amino acids.Metabolic products of microorganisms, 161st Communication. 160. Mitteilung: J. M. Müller, H. Fuhrer, J. Gruner, and W. Voser: Conocandin, ein fungistatisches Antibiotikum aus Hormococcus conorum (Sacc. et Roum.) Roback. Helv. chim. Acta 59, 2506–2514 (1976) |
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| Keywords: | Ophiocordin Antifungal antibiotic Cordyceps ophioglossoides Culture conditions Isolation Analytical data Partial structure Biological properties |
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