3D nuclear organization of telomeres in the Hodgkin cell lines U-HO1 and U-HO1-PTPN1: PTPN1 expression prevents the formation of very short telomeres including "t-stumps" |
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| Authors: | Hans Knecht Silke Brüderlein Silke Wegener Daniel Lichtensztejn Zelda Lichtensztejn Bruno Lemieux Peter Möller Sabine Mai |
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| Institution: | 1.Division d'Hématologie, CHUS,Université de Sherbrooke,Sherbrooke,Québec,Canada;2.Institute of Pathology,University of Ulm,Ulm,Germany;3.St. Elisabeth Krankenhaus,K?ln,Germany;4.Manitoba Institute of Cellular Biology,University of Manitoba,Winnipeg,Canada |
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| Abstract: | Background In cancer cells the three-dimensional (3D) telomere organization of interphase nuclei into a telomeric disk is heavily distorted
and aggregates are found. In Hodgkin's lymphoma quantitative FISH (3D Q-FISH) reveals a major impact of nuclear telomere dynamics
during the transition form mononuclear Hodgkin (H) to diagnostic multinuclear Reed-Sternberg (RS) cells. In vitro and in vivo formation of RS-cells is associated with the increase of very short telomeres including "t-stumps", telomere loss, telomeric
aggregate formation and the generation of "ghost nuclei". |
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