Sequence features involved in the mechanism of 3' splice junction wobbling |
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| Authors: | Kuo-Wang Tsai Wen-Ching Chan Chun-Nan Hsu Wen-chang Lin |
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| Institution: | (1) Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan;(2) Bioinformatics Program, Taiwan International Graduate Program, Academia Sinica, Taipei, Taiwan;(3) Institute of Bioinformatics, School of Medicine, National Yang-Ming University, Taipei, Taiwan;(4) Institute of Information Sciences, Academia Sinica, Taipei, Taiwan;(5) Information Sciences Institute, University of Southern California, Marina del Rey, CA, USA |
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| Abstract: | Background Alternative splicing is an important mechanism mediating the diversified functions of genes in multicellular organisms, and
such event occurs in around 40-60% of human genes. Recently, a new splice-junction wobbling mechanism was proposed that subtle
modifications exist in mRNA maturation by alternatively choosing at 5'- GTNGT and 3'- NAGNAG, which created single amino acid
insertion and deletion isoforms. |
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