Increased lymphocyte sister chromatid exchange frequency in workers with exposure to low level of ethylene dichloride |
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| Authors: | Tsun-Jen Cheng Pei-Yi Chou Mei-Lan Huang Chung-Li Du Ruey-Hong Wong Pau-Chung Chen |
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| Institution: | a Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan;b Center for the Research of Environmental and Occupational Diseases, College of Public Health, National Taiwan University, Taipei, Taiwan;c Institute of Occupational Safety and Health, Council of Labor Affairs, Executive Yuan, Republic of China |
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| Abstract: | The genotoxicity of low-level exposure to ethylene dichloride (EDC) and vinyl chloride monomer (VCM) in humans is not clear. We used lymphocyte sister chromatid exchange (SCE) frequency as a parameter to investigate the genotoxicity of low level EDC and VCM in VCM-manufacturing workers. The SCE frequency was determined for 51 male workers with exposure to VCM and/or EDC and for 20 male workers devoid of such exposure. Epidemiological data were obtained by questionnaire, and included history of smoking, drinking, and any medication taken, as well as a detailed occupational history. Personal- and area-sampling and analysis were conducted in order to calculate the time-weighted average (TWA) contaminant-exposure level corresponding to different job categories. Moderate EDC exposure around 1 ppm corresponded to a significantly greater SCE frequency than was the case for the low EDC exposure group (p<0.01). However, VCM exposure of similar level was not associated with increased SCE. We conclude that EDC may cause genotoxicity at a relatively low level of exposure. |
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| Keywords: | Sister chromatid exchange Smoking Vinyl chloride Ethylene dichloride |
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