Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease |
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Authors: | Kim Edy Y Battaile John T Patel Anand C You Yingjian Agapov Eugene Grayson Mitchell H Benoit Loralyn A Byers Derek E Alevy Yael Tucker Jennifer Swanson Suzanne Tidwell Rose Tyner Jeffrey W Morton Jeffrey D Castro Mario Polineni Deepika Patterson G Alexander Schwendener Reto A Allard John D Peltz Gary Holtzman Michael J |
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Institution: | Department of Medicine, 660 South Euclid Avenue, St. Louis, Missouri 63110, USA. |
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Abstract: | To understand the pathogenesis of chronic inflammatory disease, we analyzed an experimental mouse model of chronic lung disease with pathology that resembles asthma and chronic obstructive pulmonary disease (COPD) in humans. In this model, chronic lung disease develops after an infection with a common type of respiratory virus is cleared to only trace levels of noninfectious virus. Chronic inflammatory disease is generally thought to depend on an altered adaptive immune response. However, here we find that this type of disease arises independently of an adaptive immune response and is driven instead by interleukin-13 produced by macrophages that have been stimulated by CD1d-dependent T cell receptor-invariant natural killer T (NKT) cells. This innate immune axis is also activated in the lungs of humans with chronic airway disease due to asthma or COPD. These findings provide new insight into the pathogenesis of chronic inflammatory disease with the discovery that the transition from respiratory viral infection into chronic lung disease requires persistent activation of a previously undescribed NKT cell-macrophage innate immune axis. |
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