Gene conversion drives GC content evolution in mammalian histones |
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Authors: | Galtier Nicolas |
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Affiliation: | CNRS UMR 5000-Génome, Populations, Interactions, Université Montpellier 2-CC63, Place E. Bataillon, 34095, Montpellier, France. galtier@univ-montp2.fr |
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Abstract: | To examine the evolutionary influence of gene conversion on DNA base composition, I analysed an exhaustive dataset of histone paralogous genes from human and mouse. I show that those gene copies that belong to subfamilies of very similar sequences (presumably undergoing gene conversion) have a higher GC content than unique gene copies (presumably not undergoing gene conversion). Thus, it seems that gene conversion is a biased process that tends to increase the DNA GC content, a conclusion that has implications for the evolution of isochores in vertebrates. |
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