Interaction of O-(undec-10-en)-yl-D-glucose derivatives with the Plasmodium falciparum hexose transporter (PfHT) |
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Authors: | Ionita Marina Krishna Sanjeev Léo Pierre-Marc Morin Christophe Patel Asha Parbhu |
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Affiliation: | Département de Chimie Moléculaire (Serco, UMR-5250, ICMG FR-2607, CNRS), Université Joseph Fourier, BP-53, 38041, Grenoble Cedex, France. |
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Abstract: | All-O-undec-en-10-yl derivatives of d-glucose have been prepared and their affinities for the Plasmodium falciparum hexose transporter (PfHT) determined; the O-2 derivative displays a good apparent affinity for PfHT (K(I)=2 microM) with no significant interaction with the mammalian transporter GLUT1. This selectivity points to position -2 of glucose as an appropriate substitution site for the development of inhibitors of P. falciparum glucose uptake. |
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