Gene-nutrient and gene-gene interactions of controlled folate intake by Japanese women |
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Authors: | Hiraoka Mami Kato Kumiko Saito Yoko Yasuda Kazuto Kagawa Yasuo |
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Institution: | Department of Medical Chemistry, Kagawa Nutrition University, 3-9-21 Chiyoda, Sakado-shi, Saitama 350-0288, Japan. |
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Abstract: | Elevated serum total homocysteine (tHcy) levels are associated with increased risk for cardiovascular disease and dementia. The prevalence rates of homozygous mutants among Japanese women (n = 300) were 17.3%, 1.3%, 18.6%, and 5.3% for methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, reduced folate carrier (RFC-1) A80G, and methionine synthase (MS) A2756G, respectively. The tHcy value was significantly lower (p < 0.001) in young women with CC or CT of MTHFR than with TT (10.9+/-4.7 micromol/L) (n =250). Diversities of serum folate and tHcy in women with 23 combinations of different alleles at low folate intake converged to the highest (34.0+/-8.6 nmol/L) and lowest (7.6+/-1.5 micromol/L) levels, respectively, after folic acid (400 microg/day) supplementation. In the regression equation ( y= ax + b) of serum folate ( y nmol/L) plotted against mean folate intake ( x microg/day), the values of "a" were 0.032, 0.037, and 0.045 for individuals with CC, CT, and TT alleles, respectively, of MTHFR. |
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Keywords: | Folate Homocysteine Single nucleotide polymorphism Alzheimer’s disease Cardiovascular disease Reduced folate carrier Methylenetetrahydrofolate reductase Methionine synthase Recommended dietary allowances Tailor-made nutrition |
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