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Discovery of a highly orally bioavailable c-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid as a potent hypoglycemic and hypolipidemic agent |
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| Authors: | Pingali Harikishore Jain Mukul Shah Shailesh Basu Sujay Makadia Pankaj Goswami Amitgiri Zaware Pandurang Patil Pravin Godha Atul Giri Suresh Goel Ashish Patel Megha Patel Harilal Patel Pankaj |
| Institution: | Zydus Research Centre, Sarkhej-Bavla N.H 8A Moraiya, Ahmedabad 382210, India. |
| Abstract: | A series of novel 1,3-dioxane-2-carboxylic acid derivatives containing alkyl chain tether and substituted phenyl group as a lipophilic tail have been prepared as agonists of PPARalpha and gamma. c-5-6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid 13c exhibited potent hypoglycemic and lipid lowering activity with high oral bioavailability in animal models. |
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