Cinnamic esters of acyclovir-synthesis and biological activity |
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| Authors: | Stankova Ivanka Chuchkov Kiril Wutzler Peter Schmidtke Michaela |
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| Institution: | Department of Chemistry, South-West University "Neofit Rilsky", Blagoevgrad, Bulgaria. ivastankova@abv.bg |
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| Abstract: | In the present study we have synthesized esters of acyclovir with cinnamic acids (p-coumaric, ferulic, and sinapic acids) and evaluated them for their antiviral and antioxidant potential. The antiviral activity of the newly synthesized compounds has been tested against human herpes virus 1 (HSV-1) in vitro. The results indicate that none of the synthesized compounds inhibits the tested virus strain. The antioxidant properties have been studied using 2,2-diphenyl-1-picrylhydrazyl (DPPH)* test. |
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