New lignan glycosides from the root barks of Litsea glutinosa |
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Institution: | 1. Universidade Federal da Paraíba, João Pessoa, Brazil;2. Departamento de Farmácia, Universidade Estadual da Paraíba, Campina Grande, Brazil |
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Abstract: | An investigation on the chemical constituents in the root barks of Litsea glutinosa was performed for the first time. Three new lignan glycosides named Litseasins A–C (1–3), together with a known one (4), were obtained. The structures of the new compounds were established through extensive spectroscopic analyses including HR-ESI–MS, NMR, and circluar dichroism (CD). The new compounds were evaluated for their anti-inflammatory activities on lipopolysaccharide (LPS)-induce nitric oxide (NO) production in RAW264.7 murine macrophage cells. However, these compounds showed no inhibition on LPS-induced NO productions. |
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Keywords: | Dihydrobenzofuran neolignan glycosides Anti-inflammatory activities |
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