Acylphloroglucinols from the fruits of Callistemon viminalis |
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| Affiliation: | 1. Xiangya Hospital of Central South University, Changsha 410008, PR China;2. Program for Natural Products Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, PR China;3. State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, PR China;1. Department of Chemistry, Faculty of Science and Mathematics, University of Niš, Višegradska 33, 18000 Niš, Serbia;2. Institute of Physiology, Faculty of Medicine, University of Niš, Zorana Đinđića 81, 18000 Niš, Serbia;3. Faculty of Medicine, University of Niš, Zorana Đinđića 81, 18000 Niš, Serbia;4. VINČA Institute of Nuclear Science, Laboratory of Theoretical Physics and Condensed Matter Physics, 522, 11001 Belgrade, Serbia;5. School of Chemistry, University of Wollongong, 2500 Wollongong, NSW, Australia |
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| Abstract: | Five new acylphloroglucinols, callistenones L-P (1–5), and three known compounds watsonianone A, callistenones F and H were isolated from the fruits of Callistemon viminalis. Callistenones L and M possessed a bisfuran fused-ring skeleton. Compounds 3–5 were acylphloroglucinol condensed with a β-triketone moiety via a pyrane. Their structures were established from analyses of NMR spectra, CD spectra and X-ray crystallography. Compound 8 showed antibacterial activity against S. aureus with MIC value of 20.3 μg/mL and E. coli with MIC value of 15.6 μg/mL. |
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| Keywords: | Myrtaceae Acylphloroglucinols Antibacterial activity Cytotoxic activity |
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