Polycyclic monoterpenoid indole alkaloids from Alstonia rostrata and their reticulate derivation |
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| Institution: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People’s Republic of China;2. University of Chinese Academy of Sciences, Beijing 100039, People’s Republic of China;3. Germplasm Bank of Wild Species in Southwest China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People’s Republic of China;1. Chemodiversity Research Group, Department of Botany and Biodiversity Research, University of Vienna, Rennweg 14, A-1030, Vienna, Austria;2. Department of Organic Chemistry, University of Vienna, Währinger Strasse 38, A-1090, Vienna, Austria;1. Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming, 650204, Yunnan, PR China;2. Department of Organic Chemistry, University of Vienna, Währinger Strasse 38, A-1090, Vienna, Austria;3. Chemodiversity Research Group, Division of Systematic and Evolutionary Botany, University of Vienna, Rennweg 14, A-1030, Vienna, Austria;4. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, PR China;5. Drug Discovery and Development Center, Thammasat University, Rangsit Campus, Pathum Thani 12121, Thailand;1. Key Laboratory for Forest Resources Conservation and Use in the Southwest Mountains of China, Southwest Forestry University, Kunming 650224, China;2. School of Pharmacy, Wannan Medical College, Wuhu 241002, China;1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People’s Republic of China;2. University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China;3. School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, People’s Republic of China;1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China;2. University of Chinese Academy of Sciences, Beijing, 100049, China;3. Key Laboratory of Plant Diversity and Biogeography of East Asia, Chinese Academy of Sciences, Kunming, 650201, China;4. Department of Systematic and Evolutionary Botany, University of Vienna, Rennweg 14, A, 1030, Vienna, Austria |
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| Abstract: | Five new alkaloids together with 20 known ones were isolated from Alstonia rostrata, and identified on the base of NMR, MS, UV and IR spectroscopic data. Additionally, alstrostine G (1) possessed an unprecedented 6/5/6/6/5/6-ring system. The analysis of those alkaloids’ biosynthetic pathway partly indicated their reticulate metabolic relationship. The research result disclosed diverse biogenesis of monoterpenoid indole alkaloids from Alstonia rostrata speciesin combination with previous reported alstrostine A. |
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| Keywords: | Monoterpenoid indole alkaloid Alstrostines G-K Structure elucidation ECD calculation Biosynthetic relationship |
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