New cytotoxic dihydrochalcone and steroidal saponins from the aerial parts of Sansevieria cylindrica Bojer ex Hook |
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| Institution: | 1. Pharmacognosy Department, National Research Centre, Dokki, 12622 Giza, Egypt;2. Chemistry of Natural Compounds Department, National Research Centre, Dokki, 12622 Giza, Egypt;3. Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan;1. Department of Chemistry, Central University of Karnataka, Kalaburagi, 585367, India;2. Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad, 500007, India;3. Schrodinger Maestro, Bangalore, India;4. National Center For Biological Sciences, Bangalore, India;1. National and Local Union Engineering Research Center of Veterinary Herbal Medicine Resources and Initiative, Hunan Agricultural University, Changsha, 410128, China;2. School of pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China;3. Pharmaceutical Analytical & Solid-State Chemistry Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203, China;1. Department of Chemistry, University of Nairobi, P.O. Box 30197-00100, Nairobi, Kenya;2. Global Emerging Infections Surveillance (GEIS) Program, United States Army Medical Research Unit-Kenya (USAMRU-K), Kenya Medical Research Institute (KEMRI) – Walter Reed Project, P.O. Box 54 - 40100, Kisumu, Kenya;3. Institut für Chemie, Universität Potsdam, P.O. Box 60 15 53, D-14415 Potsdam, Germany;1. Department of Resources Science of Traditional Chinese Medicines, China Pharmaceutical University, Nanjing 210009, China;2. Key Laboratory of Modern Traditional Chinese Medicines, China Pharmaceutical University, Nanjing 210009, China;1. School of Pharmacy, University of Camerino, Via Sant’Agostino 1, 62032 Camerino, Italy;2. School of Science and Technology, University of Camerino, Via Sant’Agostino 1, 62032 Camerino, Italy;3. Department of Pharmacology, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey |
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| Abstract: | A new dihydrochalcone, 2‘,4‘-dihydroxy-3‘-methoxy-3,4-methylenedioxy-8-hydroxymethylene dihydrochalcone 1 and two new steroidal saponins, (25S)-ruscogenin-1-O-α-l-rhamnopyranosyl-(1 → 2)-β-d-glucopyranoside 2, (25S)-ruscogenin-3-O-α-l-rhamnopyranosyl-(1 → 4)-β-d-glucopyranoside 3, together with three known steroidal saponins (25S)-ruscogenin-3-O-β-d-glucopyranoside 4, (25S)-ruscogenin-1-O-α-l-rhamnopyranosyl-(1 → 2)-β-d-xylopyranosyl-(1 → 3)]-α-l-arabinopyranoside 5 and (25R)-26-O-β-d-glucopyranosyl-furost-5-ene-1β,3β,22α,26-tetrol-1-O-α-L-rhamnopyranosyl-(1 → 2)-β-d-xylopyranosyl-(1 → 3)]-α-l-arabinopyranoside 6 were isolated from the aerial parts of Sansevieria cylindrica. The structures of the new compounds were established by UV, IR, EI-MS, HR-ESI–MS as well as 1D (1H,13C and DEPT-135) and 2D (HSQC, HMBC and TOCSY) NMR spectral analysis. The isolated compounds 1-6 were assayed for in vitro cytotoxicities against the three human tumor cell lines HT116, MCF7 and HepG2. Compound 1 showed a moderate cytotoxicity against MCF7. Compounds 2, 3 and 6 exhibited moderate cytotoxicities against the three used cell lines and compound 5 showed marked cytotoxicities against all used cell lines. |
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| Keywords: | Dracaenaceae Dihydrochalcone Steroidal saponin Cytotoxicity |
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