Plebeins A-F,sesquiterpenoids and diterpenoids from Salvia plebeian |
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| Institution: | 1. Key Laboratory of Medicinal Chemistry for Natural Resources (Yunnan University), Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China;2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China;3. University of Chinese Academy of Sciences, Beijing 100049, PR China |
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| Abstract: | Plebein A (1), a sesquiterpenoid with a novel skeleton and another sesquiterpenoid, plebein B (2), and four new diterpenoids plebeins C-F (4–7), along with six known compounds were isolated from the whole plant of Salvia plebeia R. Br. The absolute configuration of 2 was established by an X-ray crystallographic study. In addition, compounds 4, 6 and 9 showed anti-proliferative activity against CaCo2 and MCF-7 cell lines, with IC50 values ranging from 9.65 μM to 45.96 μM. |
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| Keywords: | Sesquiterpenoid Diterpenoid Cytotoxicity |
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