Three new monoterpene glucosides and one new sorbitol ester identified from Sibiraea angustata with hypolipidemic activities in HepG2 cells |
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| Institution: | 1. Pharmacy College, Jiangxi University of Traditional Chinese Medicine, 818 Xinwan Avenue, Nanchang 330004, Jiangxi, PR China;2. Technology Center, Jiangzhong Group, 618 Huoju Road, Nanchang 330096, Jiangxi, PR China;3. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China;1. Department of Chemistry, Faculty of Science, Ege University, 35100 Bornova, Izmir, Turkey;2. Department of Chemistry, Faculty of Science, Çankırı Karatekin University, Çankırı, Turkey;1. Faculty of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650050, China;2. College of Pharmaceutical Science, Yunnan University of Traditional Chinese Medicine, Kunming 650050, China;1. Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan;2. Faculty of Pharmacy, School of Pharmaceutical Sciences, National Yang-Ming University, Taipei 112, Taiwan;3. Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan;4. Department of Forestry, National Chung-Hsing University, Taichung 402, Taiwan;5. Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan;6. Department of Cosmeceutics, China Medical University Hospital, China Medical University, Taichung 404, Taiwan;7. Department of Exercise Health Science, National Taiwan University of Physical Eucation and Sport, Taichung 404, Taiwan;8. Department of Biotechnology, Asia University, Taichung 413, Taiwan |
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| Abstract: | Three new monoterpene glycosides, sibiraglycoside L (1), M (2), N (3) and one new sorbitol ester, resibirate (4), together with four known compounds including caffeic acid glucitol ester (5), sibiscolacton C (6), geraniol-1-O-α-l-rhamnopyranosyl-(1 → 6)-1-β-d-glucopyranoside] (7), and sibiraglycoside K (8), respectively, were isolated from an aqueous extract of the aerial portion of Sibiraea angustata. Their structures were elucidated on the basis of extensive spectroscopic data analysis (including 13CNMR,1HNMR, HSQC, HMBC,1H-1H COSY, ROESY, HRESIMS, MS and CD experiments) and comparison to previously reported data. In addition, a preliminary evaluation of the hypolipidemic activities of these compounds is presented, some compounds showed moderate hypolipidemic activities in HepG2 cells. |
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| Keywords: | Rosaceae sibiraglycoside L sibiraglycoside M sibiraglycoside N Resibirate |
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