New phenolic glycosides with cyclooxygenase inhibition from the roots of Tecoma mollis |
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| Affiliation: | 1. Pharmacognosy Department, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia;2. Pharmacognosy Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt;3. Chemistry Department, Science College, Princess Noura bint Abdul Rahman University, Riyadh 11671, Saudi Arabia;4. Pharmacognosy Department, College of Pharmacy, Sattam Bin Abdulaziz University, Al-kharj 11942, Saudi Arabia;1. Faculty of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650050, China;2. College of Pharmaceutical Science, Yunnan University of Traditional Chinese Medicine, Kunming 650050, China;1. G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022, Vladivostok, Russian Federation;2. Far Eastern Federal University, 8 Sukhanova St., 690090, Vladivostok, Russian Federation;3. Botanical Garden-Institute Far Eastern Branch of the Russian Academy of Sciences, Makovskii Str. 142, 690024, Vladivostok, Russian Federation;4. Laboratory of Experimental Oncology, Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumorzentrum, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;1. Department of Chemistry, Faculty of Science, Ege University, 35100 Bornova, Izmir, Turkey;2. Department of Chemistry, Faculty of Science, Çankırı Karatekin University, Çankırı, Turkey;1. State Forestry Administration Key Open Laboratory, International Centre for Bamboo and Rattan, Beijing 100102, China;2. School of Plant Protection, Anhui Agricultural University, Hefei 230036, China;1. The Experimental Forest Management Office, National Chung Hsing University, Taichung 402, Taiwan;2. Department of Nursing, Hungkuang University, Taichung 443, Taiwan;3. Department of Biotechnology, Hungkuang University, Taichung 443, Taiwan;4. Department of Forestry, National Chung Hsiung University, Taichung 402, Taiwan;5. Graduate Institute of Pharmaceutical Science and Technology, Central Taiwan University of Science University, Taichung 406, Taiwan;6. Department of Cosmeceutics, China Medical University, Taichung 404, Taiwan;7. Department of Health and Nutrition Biotechnology, Asia University, Taichung 413, Taiwan;8. Department of Chemistry, National Taiwan University, Taipei 106, Taiwan;9. Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan;10. Department of Biotechnology, Asia University, Taichung 413, Taiwan |
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| Abstract: | Three new phenolic glycosides (1–3) together with nine known ones were isolated from the roots of Tecoma mollis using DPPH radical scavenging bioassay-guided chromatographic separation. The structures of the new compounds were established using extensive spectroscopic data and HR-MS. The antioxidant, COX-2 inhibition, and cytotoxic activities were evaluated for the isolated compounds. Compound 4 displayed the strongest radical scavenging activity relative to ascorbic acid with IC50 8.7 μM. Compounds 5, 6, and 10 showed promising COX-2 inhibitory action, IC50 values of 11.3 μM, 9.4 μM, and 13.4 μM, respectively. All compounds exhibited weak cytotoxic activity against Hela and A549 cancer cell lines. |
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| Keywords: | Phenolic glycosides Phenylpropanoids Radical scavenging activity Cycloxygenase inhibition activity Cytotoxicity |
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