Five new indole derivatives from the cyanobacterium Moorea producens |
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| Affiliation: | 1. Department of Ocean Sciences, Tokyo University of Marine Science and Technology, Tokyo 108-8477, Japan;2. National Research Institute of Fisheries Science, Yokohama, 236-8648, Japan;1. Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt;2. National Center for Natural Products Research, School of Pharmacy, University of Mississippi, MS 38677, USA;3. Department of Pharmacognosy, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt;4. Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt;1. Laboratório de Bioprospecção Fitoquímica, Universidade Federal Rural de Pernambuco, 52171-900, Recife, PE, Brazil;2. Departamento de Antibióticos, Universidade Federal de Pernambuco, 52171-011, Recife, PE, Brazil;3. Laboratório de Farmacologia e Imunidade, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, 57072-900, Maceio, AL, Brazil;1. Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood Street, Chicago, IL 60612, United States;2. Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, United States;3. Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood Street, Chicago, IL 60612, United States;1. Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, United States;2. Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood Street, Chicago, IL 60612, United States;1. School of Pharmacy, Anhui University of Chinese Medicine, Anhui Key Laboratory of Modern Chinese Materia Medica, Hefei 230012, China;2. Synergetic Innovation Center of Anhui Authentic Chinese Medicine Quality Improvement, Hefei 230012, China;3. Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China;4. The First Affiliated Hospital, Anhui University of Chinese Medicine, Hefei 230038, China |
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| Abstract: | Chemical analysis of the hydrophilic fraction from marine cyanobacterium Moorea producens extracts led to the isolation of five new indole derivatives (1-5). So far, 2-formyl-4,5,6,7-tetrahydroindole has been reported only for 6 from the nature, consequently compounds 1-5 were the second representatives of this class. Cytotoxicity, diatom growth inhibition, and antibacterial activity tests for compounds 1-5 showed no bioactivity at the concentration tested. |
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| Keywords: | Cyanobacteria Moorea producens Indole Structural elucidation Bioactivity |
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