New cytotoxic protolimonoids from the stem bark of Aglaia argentea (Meliaceae) |
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| Affiliation: | 1. Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia;2. Central Laboratory of Universitas Padjadjaran, Jatinangor 45363, Indonesia;3. Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, 59100, Malaysia;4. Department of Food, Life and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata, 997-8555, Japan;1. Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata, 997-8555, Japan;2. The United Graduate School of Agricultural Sciences, Iwate University, Morioka, Iwate, 020-8550, Japan;3. Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Tanjungpura, Pontianak, 78124, Indonesia;4. Department of Geography, Faculty of Mathematics and Natural Sciences Universitas Negeri Makassar, Makassar, 90224, Indonesia;5. Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Sumedang 45363, Indonesia;6. Graduate School of Arts and Sciences, Graduate Course in Biological Chemistry and Food Sciences, Iwate University, Morioka, Iwate, 020-8550, Japan;1. Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata 997-8555, Japan;2. Research and Analytical Center for Giant Molecules, Graduate School of Science, Tohoku University, Sendai, Miyagi 980-8576, Japan;3. Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Sumedang 45363, Indonesia;4. Graduate School of Agriculture, Iwate University, Morioka, Iwate 020-8550, Japan;1. Natural Products Research Unit, Center of Excellence for Innovation in Chemistry (PERCH-CIC), Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand;2. Department of Microbiology, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand;3. Department of Biology, Faculty of Science, Srinakharinwirot University, Bangkok, 10110, Thailand;4. Department of Biochemistry, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand;5. Department of Physics, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand;6. Institute of Nanomaterials Research and Innovation for Energy, Khon Kaen University, Khon Kaen, 40002, Thailand;7. Materials Chemistry Research Center, Center of Excellence for Innovation in Chemistry (PERCH-CIC), Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand;1. Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata, 997-8555, Japan;2. Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Garut, Garut, 44151, Indonesia;3. Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, 45363, Indonesia;4. Faculty of Pharmacy, Universitas Mulawarman, Samarinda 75123, Kalimantan Timur, Indonesia |
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| Abstract: | Two new protolimonoid compounds, namely, argentinin A (1) and B (2) along with five known triterpenoid compounds, dammar-24-en-3α-ol (3), 3-epi-cabraleahydroxy lactone (4), (E)-25-hydroperoxydammar-23-en-3β,20-diol (5), mixture of eichlerianic acid and shoreic acid (6a and 6b), and dammar-24-en-3α,20-diol (7), were isolated from the stem bark of Aglaia argentea. The structure of new compounds were elucidated by spectroscopic methods including one and two-dimensional NMR as well as high-resolution mass spectrometric analysis. All of the compounds were tested for their cytotoxic effects against P-388 murine leukemia cells in vitro. Among those isolated compounds, argentinin A (1) showed the strongest activity with an IC50 value of 1.27 μg/mL (3.05 μM). |
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| Keywords: | Argentinin A and B Protolimonoid Triterpenoid Cytotoxic activity |
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