Illigerones A and B,two new long-chain secobutanolides from Illigera henryi W. W. Sm. |
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| Affiliation: | 1. CAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization & Ecological Restoration and Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, PR China;2. Southwest University for Nationalities, Chengdu 610041, PR China;3. Syngenta Jealott’s Hill International Research Centre, Berkshire RG42 6EY, UK;1. Key Laboratory of Tibetan Medicine Research of CAS and Key Laboratory for Tibetan Medicine of Qinghai Province, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, PR China;2. Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China;1. Marine Drugs Research Center, College of Pharmacy, Jinan University, Guangzhou 510632, China;2. State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, and Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China;1. Chulabhorn Research Institute, Kamphaeng Phet 6, Talat Bang Khen, Lak Si, Bangkok 10210, Thailand;2. Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand;1. Unidad de Biotecnología, Centro de Investigación Científica de Yucatán, A.C. (CICY), Calle 43 #130 (32 y 34), Col. Chuburná de Hidalgo, Mérida, Yucatán, 97205, Mexico;2. Unidad de Investigación Médica, Centro Médico Ignacio García Téllez, Instituto Mexicano del Seguro Social (IMSS), Calle 41 No. 439, Col. Industrial, Mérida, Yucatán, 97150, Mexico |
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| Abstract: | Two new long-chain secobutanolides, illigerones A (1) and B (2), together with five known compounds, actinodaphnine (3), cryptodorine (4), β-sitosterol (5), daucosterol (6), and stigmasterol (7) were isolated from Illigera henryi W. W. Sm. The structures of 1 and 2 were identified by HRESIMS, EIMS, 1D/2D NMR, and electronic circular dichroism (ECD) spectra. Compound 1 exhibited the moderate cytotoxic activities against five tumour cells. This is the first report of secobutanolides isolated from plants of Hernandiaceae. |
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| Keywords: | Secobutanolide Illigerone A Illigerone B Cytotoxic activity |
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