Bioactive 2-pyrone metabolites from an endophytic Phomopsis asparagi SWUKJ5.2020 of Kadsura angustifolia |
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| Institution: | 1. Department of Toxicology and Pharmacology, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;2. Department of Microbiology, Islamic Azad University, Tehran North Branch, Tehran, Iran;3. Computer Science and Informatics Department, EMORY University School of Medicine, Atlanta, GA, USA;4. Department of Toxicology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran;5. Environmental and Occupational Hazards control Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;6. Department of Occupational Hygiene, School of Public Health, Shahid Beheshti University, Tehran, Iran. |
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| Abstract: | Five new 2-pyrone metabolites, phomaspyrones A–E (1–5) along with three known compounds, macommelin-8,9-diol (6), macommelin-9-ol (7), and macommelin (8), were isolated from the culture broth of an endophytic fungus Phomopsis asparagi SWUKJ5.2020 of medicinal plant Kadsura angustifolia by sequentially purification over silica gel, Sephadex LH-20 column chromatography and preparative HPLC. Their structures were elucidated on the basis of spectroscopic analysis, including two-dimensional (2D) NMR and HRMS (ESI-TOF) data. Among them, compounds 3–5 exhibited notable cytotoxicity against HL-60 and K562 cells with IC50 values of below 10 μg/mL better than those of the other isolated metabolites (IC50 = 10.6–26.6 μg/mL). The results showed that the keto or hemiketal functionality might play an important role in cytotoxic activity of this class of compounds. |
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| Keywords: | 2-Pyrone Phomaspyrone Cytotoxicity |
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