Stachaegyptin A-C: Neo-clerodane diterpenes from Stachys aegyptiaca |
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Institution: | 1. Phytochemistry Department, National Research Centre,33 El-Bohouth St., Dokki, Giza, 12622, Egypt;2. Biology Unit, Central Laboratory for Pharmaceutical and Drug Industries Research Division, National Research Centre,33 El-Bohouth St., Dokki, Giza, 12622, Egypt;3. Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt;4. Department of Chemistry & Biochemistry Texas Tech University, Lubbock, TX 79409, USA;1. Facultad de Ciencias Exactas, Universidad Nacional de Salta (UNSa), 4400 Salta, Argentina;3. Universidad de Buenos Aires, Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, Pabellón 2 – (1428), Buenos Aires, Argentina;4. CONICET-Universidad de Buenos Aires, Unidad de Microanálisis y Métodos Físicos en Química Orgánica (UMYMFOR), Buenos Aires, Argentina;1. Faculty of Chemistry, VNUHCM–University of Science, 227 Nguyen Van Cu Street, Ho Chi Minh City, Viet Nam;2. Institute of Tropical Biology, VAST, 85 Tran Quoc Toan, Ho Chi Minh City, Viet Nam;3. VNUHCM–School of Medicine and Pharmacy, Quarter 6, Linh Trung Ward, Thu Duc District, Ho Chi Minh City, Viet Nam;1. Dipartimento di Chimica, Università di Roma “La Sapienza”, Piazzale Aldo Moro, 5–00185 Roma, Italy;2. Dipartimento di Biologia Ambientale, Università di Roma “La Sapienza”, Piazzale Aldo Moro, 5–00185 Roma, Italy;3. Dipartimento di Chimica e Tecnologia del Farmaco, Università di Roma “La Sapienza”, Piazzale Aldo Moro, 5–00185 Roma, Italy;1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, PR China;2. University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, PR China;3. School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210029, PR China |
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Abstract: | Phytochemical investigation of Stachys aegyptiaca resulted in the characterization of three new diterpenes (1-3) together with eleven known compounds including four neo-clerodane diterpenes and seven flavonoid aglycones. Structure elucidation was performed by spectroscopic analysis by HRFABMS, 1D and 2D NMR and X-ray. Isolated compounds were screened for anti-inflammatory activity using a lipopolysaccharide-induced nitric oxide inhibition assay employing murine macrophage cells. Among the assayed compounds, 13 (calycopterin) showed a concentration-dependent inhibition of LPS-induced nitric oxide release with a IC50 of 62.5 μM. |
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Keywords: | Lamiaceae Diterpenes Flavonoids Anti-inflammatory activity |
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