Bioactive mexicanolide-type limonoids from the fruits of Trichilia connaroides |
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| Affiliation: | 1. Marine Drugs Research Center, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, PR China;2. Center for Marine Biodiversity, University of Kerala, Kariavattom, Thiruvananthapuram 695581, Kerala, India;1. Facultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México. Circuito Exterior, Ciudad Universitaria. Delegación Coyoacán, Ciudad de México 04510, México;2. Department of Pharmacology and Physiology, Université de Montréal, Montréal, Québec, Canada;3. Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, Departamento de Fisiología de la Nutrición, Ciudad de México, México;4. Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, Departamento de Nefrología y Metabolismo Mineral, Ciudad de México, México |
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| Abstract: | Two new mexicanolide-type limonoids, trichiconnarones A (1) and B (2), along with six known analogues (3–8), were isolated from the fruits of Trichilia connaroides. The structures of 1 and 2 were elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons their data with those reported in the literatures. All new compounds were evaluated for their anti-inflammatory activities via examining the inhibitory activity on nitric oxide (NO) production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells in vitro. Compounds 1 and 2 exhibited inhibitory effects with IC50 values comparable to that of hydrocortisone. |
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| Keywords: | Mexicanolide-type limonoids Trichiconnarones A and B Nitric oxide production inhibition |
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