Lanostane triterpenoids from cultivated fruiting bodies of the basidiomycete Ganoderma orbiforme |
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| Affiliation: | 1. National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand;2. Biodiversity-Based Economy Development Office, The Government Complex,Chaeng Wattana Road, Bangkok, 10210, Thailand;1. College of Pharmacy, Academy of Integrative Medicine, Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian 116044, People’s Republic of China;2. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China;1. Departamento de Ciencias Experimentales y Matemáticas, Facultad de Veterinaria y Ciencias Experimentales, Universidad Católica de Valencia San Vicente Mártir, Guillem de Castro-94, E-46001 València, Spain;2. Institut Universitari de Ciència Molecular, Universitat de València, P.O. Box 22085, E-46071 València, Spain |
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| Abstract: | A new 3,4-seco-27-norlanostane triterpene, ganoboninketal D (1), a new lanostane, (24S)-3-oxo-7α,24,25-trihydroxylanosta-8-ene (2), together with six known lanostanes (3–8), were isolated from cultivated fruiting bodies of the basidiomycete Ganoderma orbiforme. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data, and the structures 1 and 2 were further confirmed by chemical correlations to ganoboninketal C and ganodermanondiol, respectively. All isolated compounds were inactive in the antitubercular and antimalarial activity assays against Mycobacterium tuberculosis H37Ra and Plasmodium falciparum K1, respectively, except that compound 8 exhibited weak antitubercular activity (MIC 50 μg/ml). |
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| Keywords: | Ganodermataceae Lanostane triterpenes Antitubercular activity |
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