Labdane and norlabdane diterpenoids from the aerial parts of Leonurus japonicus |
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| Institution: | 1. Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama 930-0194, Japan;2. Department of Chemistry, University of Yangon, Yangon 11041, Myanmar;3. Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan;4. Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan;1. Faculty of Chemistry, University of Science, VNU-HCM, 227 Nguyen Van Cu, Ho Chi Minh City, Viet Nam;2. Faculty of Pharmacy, Ton Duc Thang University, 19 Nguyen Huu Tho, Ho Chi Minh City, Viet Nam;3. Institute of Tropical Biology, VAST, 85 Tran Quoc Toan, Ho Chi Minh City, Viet Nam |
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| Abstract: | A new labdane diterpenoid, leojaponicin (1), a novel norlabdane, methyl 15,16-dinor-7-oxolabda-8-ene-14-oate (2), along with four known labdanes, hispanone (3), leoheteronins A (4) and B (5), 15-methoxyleoheteronin B (6), and three norlabdanes, 14,15,16-trinor-7-oxolabda-8-ene-13-oic acid (7), methyl 14,15,16-trinor-7-oxolabda-8-ene-13-oate (8), 14,15-dinor-8-labdene-7,13-dione (9), and a steroid, stigmast-4-ene-3-one (10), were isolated from a hexane extract of Leonurus japonicus. Their structures were determined using spectroscopic methods, mainly 1-D and 2-D NMR. Compounds 7 and 8 were previously semisynthesized but are reported here for the first time as naturally occurring compounds. In addition, α-glucosidase inhibitory activity of the isolated compounds was evaluated and compound 6 exhibited the strongest effect with IC50 value of 26.7 μM (compared with the positive control acarbose, IC50 = 214.5 μM). |
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| Keywords: | Structure determination Labdanes Norlabdanes α-Glucosidase inhibition |
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