Pro-apoptotic activity of acylated triterpenoid saponins from the stem bark of Albizia chevalieri harms |
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| Affiliation: | 1. Pharmacognosie et Molécules Naturelles Bioactives, Laboratoire d’Innovation Thérapeutique, UMR 7200, CNRS-Université de Strasbourg, Faculté de Pharmacie, 74 route du Rhin, F-67401 Illkirch Cedex, France;2. Laboratoire de Pharmacochimie des Substances Naturelles, Département de Chimie Organique, Faculté de Sciences, Université de Yaoundé I, BP 812 Yaoundé, Cameroon;3. Institut de Recherche Agricole pour le Développement (IRAD), BP 2067 Yaoundé, Cameroon;4. UMI 3189, FMPO, University Anta Diop of Dakar, Senegal;5. UFR Médecine-Pharmacie, CNRS-UMR7312, 51 rue Cognacq Jay, 51100 Reims, France;6. Institut Pluridisciplinaire Hubert Curien, UMR 7178 CNRS Université de Strasbourg, 74 route du Rhin, F-67401 Illkirch Cedex, France 67401Illkirch, France;1. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China;2. Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards, Guangxi Institute of Traditional Medical and Pharmaceutical Sciences, Nanning 530022, PR China;3. College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, PR China;1. Area Major Laboratory of Protection and Utilization of Traditional Chinese Medicine, Beijing Normal University, Haidian District, Beijing 100088, PR China;2. College of Material Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, PR China;3. State Key Laboratory Breeding Base of Dao-di Herbs, China Academy of Chinese Medical Sciences, Beijing 100700, PR China;4. School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology, Jinan 250353, PR China;1. Micro-Optoelectronic and Nanostructure Laboratory, Faculty of Sciences, Monastir University, Environnement Avenue, 5019 Monastir, Tunisia;2. Laboratoire de Chimie de Coordination, CNRS UPR-8241 and Université de Toulouse, UPS, INPT, F-31077 Toulouse, France;3. Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands;1. Departamento de Química Inorgánica, Universidad de Granada, 18071 Granada, Spain;2. Unidad de Rayos X, RIAIDT Edificio CACTUS, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain;3. Departamento de Química Analítica, Universidad de Granada, 18071 Granada, Spain;4. Departamento de Química Aplicada, Facultad de Ciencias Químicas de San Sebastián, UPV/EHU, 20018 San Sebastián, Spain;1. Department of Clinical Science and Education, Karolinska Institutet, Stockholm, Sweden;2. Sachs'' Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden |
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| Abstract: | As a continuation of our interest in apoptosis-inducing triterpenoid saponins from Albizia genus, phytochemical investigation of the stem bark of Albizia chevalieri led to the isolation of three new oleanane-type saponins, named chevalierosides A–C (1–3). Their structures were established on the basis of extensive analysis of 1D and 2D NMR (1H-, 13C NMR, DEPT, COSY, TOCSY, ROESY, HSQC and HMBC) experiments, HRESIMS studies, and by chemical evidence. The pro-apoptotic effect of the three saponins was evaluated on two human cell lines (pancreatic carcinoma AsPC-1 and hematopoietic monocytic THP-1). Cytometric analyses showed that saponins 1–3 induced apoptosis of both human cell lines (AsPC-1 and THP-1) in a dose-dependent manner. |
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| Keywords: | Mimosaceae Triterpenoid saponins Proapoptotic activity Pancreatic carcinoma AsPC-1 |
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