Three new arylbenzofurans from Lavandula angustifolia and their bioactivities |
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| Institution: | 1. Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co., Ltd, Kunming, PR China;2. School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Nature Products, Kunming, PR China;1. Department of Chemistry, University of Douala, Faculty of Sciences, 24157 Douala, Cameroon;2. Natural Products Research Group, Department of Chemistry, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, GU2 7XH, United Kingdom;3. Organic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, 33501 Bielefeld, Germany;1. Faculty of Science, Department of Chemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon;2. Service Commun d’Analyses, Institut de Chimie Moléculaire de Reims (ICMR), CNRS UMR 7312, Bat. 18 B.P. 1039, 51687 Reims Cedex 2, France;3. Groupe Isolement et Structure, Institut de Chimie Moléculaire de Reims (ICMR), CNRS UMR 7312, Bat. 18 B.P. 1039, 51687 Reims Cedex 2, France;1. Institute of Launch Dynamics, Nanjing University of Science and Technology, Nanjing City 210094, China;2. College of Optoelectronic Engineering, Chongqing University, Chongqing City 400044, China;1. College of Pharmacy, Guizhou University, Guiyang 550025, Guizhou, PR China;2. The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, Guizhou, PR China;3. The Key Laboratory of Chemistry for Natural Products of Guizhou Medical University, Guiyang 550002, Guizhou, PR China;4. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, Hainan, PR China;1. Key Laboratory of Plant Resources Conservation and Sustainable Utilization/Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China;2. Guangdong Provincial Key Laboratory of Bio-Control for the Forest Disease and Pest, Guangdong Academy of Forestry, Guangzhou 510520, China;3. Shaanxi Academy of Traditional Chinese Medicine, Xian 710003, China;4. College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China |
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| Abstract: | Three new arylbenzofurans, 2-(7-methoxy-2-(4-methoxyphenyl)-3-methylbenzofuran-5-yl)ethanol (1), 4-(5-(2-hydroxyethyl)-7-methoxy-3-methylbenzofuran-2-yl)phenol (2), and 2-(6-methoxy-2-(4- methoxyphenyl)-3-methylbenzofuran-5-yl)ethanol (3), together with three known ones (4–6) were isolated from the whole plant of Lavandula angustifolia. Their structures were determined by means of HRESIMS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1–3 and 5 were tested for their anti-tobacoo mosaic virus (TMV) activities, and Compounds 1–6 were tested for their cytotoxicity activities. In our assay, Compounds 1–3 showed high anti-TMV activity with inhibition rate of 38.2, 35.2, and 34.0%, which superior to positive control Ningnanmycin. Compounds 1–6 also showed weak inhibitory activities against some tested human tumor cell lines with IC50 values in the range of 2.2–8.2 μM. |
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| Keywords: | Arylbenzofurans Anti-tobacoo mosaic virus activity Cytotoxicity activity |
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