A constituent of Alpinia katsumadai suppresses allergic airway inflammation |
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| Institution: | 1. Department of Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea;2. High-Enthalpy Plasma Research Center, Chonbuk National University, Republic of Korea;3. Division of Marine Environment & Bioscience, Korea Maritime University, Busan, Republic of Korea;4. Biochip Research Center and Inflammatory Disease Research Center, Hoseo University, 165, Sechul-ri, Baebang-myun, Asan, Chungnam 336-795, Republic of Korea;5. Regional Innovation Center and Inflammatory Disease Research Center, Hoseo University, 165, Sechul-ri, Baebang-myun, Asan, Chungnam 336-795, Republic of Korea;6. Oriental Bio-herb Research Institute, Kangwon National University, Chuncheon 200-701, Republic of Korea;7. School of Biomedical Sciences, Charles Sturt University, Bathurst, NSW 2795, Australia |
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| Abstract: | Two new compounds, named as (3R)-5,7-dihydroxy-3-isopropyl-3-methylisochroman-1-one (1), and (1R,3R,4S)-1-(4′-methyl-phenyl)-3,4-dihydro-3,4-dimethyl-1H-2-benzopyran-5,6,8-triol (2), were isolated from seeds of Alpinia katsumadai Hayata. Structures of compounds 1 and 2 were elucidated and determined on the basis of spectroscopic analysis. Additionally, compound 1 significantly suppressed allergic airway inflammation induced by OVA through reducing airway hyperresponsiveness. Moreover, the inflammation suppression was associated with a marked decrease in the Th2 cytokines and IgE production. |
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| Keywords: | Asthma Allergic airway inflammation Airway hyperresponsiveness |
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