Benzoate esters and flavonoids from Desmos pedunculosus |
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| Institution: | 1. National and Local Union Engineering Research Center of Veterinary Herbal Medicine Resources and Initiative, Hunan Agricultural University, Changsha, 410128, China;2. School of pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China;3. Pharmaceutical Analytical & Solid-State Chemistry Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203, China;1. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China;2. Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards, Guangxi Institute of Traditional Medical and Pharmaceutical Sciences, Nanning 530022, PR China;3. College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, PR China;1. School of Pharmacy, Anhui University of Chinese Medicine, Anhui Key Laboratory of Modern Chinese Materia Medica, Hefei 230012, China;2. Synergetic Innovation Center of Anhui Authentic Chinese Medicine Quality Improvement, Hefei 230012, China;3. Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China;4. The First Affiliated Hospital, Anhui University of Chinese Medicine, Hefei 230038, China;1. CRID Center, NeoPharm Co., Ltd., Daejeon, Republic of Korea;2. College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea;3. Department of Immunology, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of Korea;4. College of Pharmacy, Chungbuk National University, Cheongju, Republic of Korea;5. Department of Bio-Cosmetic Science, Seowon University, Cheongju, Republic of Korea;6. Department of Dermatology, Atopy and Asthma Center Seoul Medical Center, Seoul, Republic of Korea;1. Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Huachiew Chalermprakiet University, Samutprakarn 10540, Thailand;2. Nationaal Herbarium Nederland, Leiden University, The Netherlands;3. Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand;4. Département de Physico-chimie du Medicament, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, Paris 75006, France;5. Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand |
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| Abstract: | The genus Desmos (Annonaceae) is comprised of about thirty-three species of trees and shrubs found in southern Asia, Indonesia, and northern Australia. The chemistry of many of these species is largely unreported. Phytochemical investigation of a methanol extract of the aerial parts of D. pedunculosus led to the isolation of two flavonoids and eight benzoate ester derivatives. Three of these benzoate esters are new compounds, while two others are known synthetic compounds reported here as natural products for the first time. The compounds were characterized by mass spectrometry and 1D and 2D NMR spectroscopy. Based on a comparison of extracts of D. chinensis and D. pedunculosus from Vietnam, several of the compounds we report may serve as marker compounds to chemically distinguish these similar species. |
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| Keywords: | Phenylpropanoid Induced circular dichroism |
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