Curvularin derivatives from the soil-derived fungus Aspergillus polyporicola PSU-RSPG187 |
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| Affiliation: | 1. Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand;2. CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China;3. University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, China;4. Department of Microbiology and Natural Products Research Center of Excellence, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand;5. National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Klong Luang, Pathumthani 12120, Thailand;1. CNRS, Université Paris-Sud, Institut de Chimie des Substances Naturelles, 1 avenue de la Terrasse, 91198 Gif-sur-Yvette cedex, France;2. CNRS/Sorbonne Universités, LBBM, Observatoire Océanologique, 66650 Banyuls-sur-mer, France;1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, People’s Republic of China;2. University of Chinese Academy of Sciences, Beijing, 100049, People’s Republic of China;1. Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University Düsseldorf, Universitätsstraße 1, 40225 Düsseldorf, Germany;2. Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, 266003 Qingdao, PR China;3. Department of Organic Chemistry, University of Debrecen, P.O.B. 400, 4002 Debrecen, Hungary;4. Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstraße 1, 40225 Düsseldorf, Germany;5. Institute of Complex Systems: Strukturbiochemie, Forschungszentrum Jülich, Wilhelm-Johnen-Straße, 52428 Jülich, Germany;6. State Key Laboratory of Natural and Biomimetic Drugs, Beijing University, 100191 Beijing, PR China |
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| Abstract: | Two new curvularin derivatives, curvulopyran (1) and ent-curvulone A (2), along with ten known compounds including five cytochalasins and five curvularins, were isolated from a culture broth of the soil-derived fungus Aspergillus polyporicola PSU-RSPG187. Their structures were determined by spectroscopic methods. Known aspochalasin D displayed moderate antifungal activity against flucytosine–resistant Cryptococcus neoformans with an MIC value of 32 μg/mL and showed no cytotoxic activity against noncancerous cell lines. In addition, known α,β–dehydrocurvularin exhibited potential cytotoxic activity against both KB and MCF-7 cell lines with the IC50 values of 11.26 and 19.50 μM. Unfortunately, it was strongly active against Vero cell lines. |
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| Keywords: | Cytochalasins Curvularins Soil-derived fungi Antimicrobial activity Cytotoxic activity |
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