Two new lactones from whole herbs of Patrinia villosa Juss |
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| Institution: | 1. School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China;2. Chinese People’s Liberation Army 210 Hospital, Dalian 116021, People’s Republic of China;1. National and Local Union Engineering Research Center of Veterinary Herbal Medicine Resources and Initiative, Hunan Agricultural University, Changsha, 410128, China;2. School of pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China;3. Pharmaceutical Analytical & Solid-State Chemistry Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203, China;1. College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, PR China;2. State Key Laboratory of Innovative Drug and Efficient Energy-Saving Pharmaceutical Equipment, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, PR China;1. Department of Resources Science of Traditional Chinese Medicines, China Pharmaceutical University, Nanjing 210009, China;2. Key Laboratory of Modern Traditional Chinese Medicines, China Pharmaceutical University, Nanjing 210009, China;1. School of Pharmacy, Anhui University of Chinese Medicine, Anhui Key Laboratory of Modern Chinese Materia Medica, Hefei 230012, China;2. Synergetic Innovation Center of Anhui Authentic Chinese Medicine Quality Improvement, Hefei 230012, China;3. Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China;4. The First Affiliated Hospital, Anhui University of Chinese Medicine, Hefei 230038, China;1. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China;2. Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards, Guangxi Institute of Traditional Medical and Pharmaceutical Sciences, Nanning 530022, PR China;3. College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, PR China |
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| Abstract: | Chemical investigation of 70% EtOH exact of Patrinia villosa Juss. led to the isolation, purification and identification of two new lactones (1-2) along with twelve known compounds (3-14). Their structures were established by comprehensive spectroscopic analyses. All compounds were evaluated for their cytotoxic activities against A549, HepG2, Hep3 B and MCF-7 cancer cell lines. Compounds 1, 8, 10, 11 and 12 displayed weak cytotoxic activities against MCF-7 cell line. In addition, compounds 1, 2, 8, 10, 11 and 12 were also tested their antimicrobial activities against Micrococcus luteus. Unfortunately, these compounds were found to be inactive. |
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| Keywords: | Lactones Cytotoxicity Antimicrobial |
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