Enhancement by N-hydroxysulfosuccinimide of water-soluble carbodiimide-mediated coupling reactions |
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| Authors: | J V Staros R W Wright D M Swingle |
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| Institution: | 1. Department of Visceral Surgery, Niort Hospital, Niort, France;2. BluePharm Consulting, 17 rue Davioud, 75016 Paris, France |
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| Abstract: | Water-soluble carbodiimides are frequently employed in coupling or conjugation reactions, e.g., to link a peptide immunogen to a carrier protein. However, their utility is limited by low coupling yields obtained under some conditions. We have found that addition of N-hydroxysulfosuccinimide to such reactions can greatly enhance the yields obtained. |
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