Effect of dietary carbohydrates and copper status on blood pressure of rats |
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Authors: | M Fields RJ Ferretti J Cecil Smith S Reiser |
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Institution: | 1. Georgetown University School of Medicine Washington, DC 20007, USA;2. Vitamin and Mineral Nutrition Laboratory & Carbohydrate Nutrition Laboratory Beltsville Human Nutrition Research Center USDA, Beltsville, MD 20705, USA |
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Abstract: | Copper deficiency was induced in rats by feeding diets containing either 62% starch, fructose or glucose deficient in copper for 6 weeks. All copper deficient rats, regardless of the dietary carbohydrate, exhibited decreased ceruloplasmin activity and decreased serum copper concentrations. Rats fed the fructose diet exhibited a more severe copper deficiency as compared to rats fed either starch or glucose. The increased severity of the deficiency was characterized by reduced body weight, serum copper concentration and hematocrit. In all rats fed the copper adequate diets, blood pressure was unaffected by the type of dietary carbohydrate. Significantly reduced systolic blood pressure was evident only in rats fed the fructose diet deficient in copper. When comparing the three carbohydrate diets, the physiological and biochemical lesions induced by copper deprivation could be magnified by feeding fructose. |
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Keywords: | Address reprint request to: Meira Fields USDA Beltsville Human Nutrition Research Center Vitamin and Mineral Nutrition Laboratory Room 215 Bldg 307 Beltsville MD 20705 |
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