The vasorelaxant effect of (±)-15-deoxy-16-hydroxy-16(α/β)-vinyl-prostaglandin E2 (CL 115,129) and its methyl ester (CL 115,347) on the isolated ductus arteriosus preparation |
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| Authors: | FM Lai TK Tanikella P Cervoni |
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| Institution: | Department of Cardiovascular Biological Research Medical Research Division, American Cyanamid Company Lederle Laboratories, Pearl River, New York 10965, USA |
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| Abstract: | CL 115,129 and its methyl ester, CL 115,347, were studied for their vasorelaxant effects and compared to that of prostaglandin (PG) E2 and its methyl ester on isolated ductus arteriosus (DA) from fetal lambs and rabbits. CL 115,129 and CL 115,347 potently relaxed the oxygen-indomethacin constricted ductus in a concentration dependent manner. The threshold concentration was 1×10?13M and the estimated EC50's (M) were 6.9×10?8 and 4.3×10?8, respectively, for CL 115,129 and CL 115,347. Also confirmed was the vasorelaxant ability of PGE2. These studies indicate that the CL compounds possess potent vasorelaxant effects on the DA although less potent than PGE2 or its methyl ester. |
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