2-Pyrrolidinone and succinimide endogenously present in several mammalian species |
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| Authors: | E.F. Bandle G. Wendt U.B. Ranalder K.-H. Trautmann |
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| Affiliation: | Pharmaceutical Research Department F. Hoffmann-La Roche & Co., Ltd. CH-4002 Basle, Switzerland |
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| Abstract: | 2-Pyrrolidinone and succinimide were identified in blood plasma of man, rat, and mouse. Dog plasma contained only traces of 2-pyrrolidinone not exceeding significantly the detection limit of our GCMS-method. Succinimide but not 2-pyrrolidinone could also be found in the brains of rat and mouse. Evidence is presented for a metabolic pathway leading from 2-pyrrolidinone to succinimide, with 5-hydroxy-2-pyrrolidinone as an intermediate. |
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| Keywords: | To whom reprint requests should be addressed. |
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