Effect of aging on recovery of striatal dopamine receptors following n-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (EEDQ) blockade期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Effect of aging on recovery of striatal dopamine receptors following n-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (EEDQ) blockade

Authors:	Jacquelyn M. Henry George S. Roth

Affiliation:	Molecular Physiology and Genetics Section, Laboratory of Cellular and Molecular Biology, Geronthology Research Center, National Institute on Aging, National Institutes of Health, Baltimore City Hospitals, Baltimore, Maryland 21224, U.S.A.

Abstract:	The recovery rate of striatal dopamine receptors following blockade by N-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (EEDQ) $in vivo$ is reduced by 25–35% in striata from senescent Wistar rats when compared to mature counterparts. No differences in binding affinity for [³H]-spiperone were observed for the different age groups at various times after EEDQ injection. These results suggest that loss of striatal dopamine receptors during aging may be due to a decreased biosynthetic rate.

Keywords:
本文献已被 ScienceDirect 等数据库收录！