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The antagonism of bombesin in the CNS by substance P analogues |
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| Authors: | Anthony T Yachnis Jacqueline N Crawley Robert T Jensen Margaret M McGrane Terry W Woody |
| Institution: | 1. Department of Biochemistry, The George Washington University School of Medicine and Health Sciences, Washington, D.C. 20037, USA;2. Psychobiology Branch, The National Institute of Mental Health, USA;3. Digestive Disease Branch, National Institute of Digestive and Kidney Disease, Bethesda, MD 20205, USA |
| Abstract: | The ability of substance P analogues to inhibit the action of bombesin in the CNS was investigated using receptor binding and biological assays. The putative substance P antagonists inhibited binding to central receptors for both substance P and bombesin-like peptides. Spantide, which was the most potent analogue tested, reversed the bombesin induced hypothermia and grooming. Therefore the putative substance P antagonists may also antagonize the actions of bombesin in the CNS |
| Keywords: | Address all correspondence to Dr Terry W Moody |
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