Getting (chromosomes) loaded--a new role for timeless |
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| Authors: | Golden Andy Cohen-Fix Orna |
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| Affiliation: | Laboratory of Biochemistry and Genetics, NIDDK, NIH, Bethesda, MD 20892, USA. |
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| Abstract: | A recent study in C. elegans reveals an unanticipated link between sister chromatid cohesion and the TIM-1 protein, a homolog of the Drosophila circadian rhythm protein TIMELESS. The phenotypes of tim-1 mutants suggest that cohesin subunits load onto chromosomes in a stepwise manner. Whether TIM-1 is also involved in circadian rhythms is discussed. |
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