Effects of prostaglandins on the spreading, adhesion and migration of mouse peritoneal macrophages |
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| Authors: | Walter D Cantarow Hou Tak Cheung G Sundharadas |
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| Institution: | Immunobiology Research Center and the Department of Medical Microbiology, University of Wisconsin, Madison, Wisconsin 53706, USA |
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| Abstract: | The effects of prostaglandins on the
properties of mouse peritoneal macrophages namely spreading, adhesion and migration were investigated. PGE1 and PGE2 inhibit the spreading and adhesion of complete Freund's Adjuvant induced peritoneal macrophages significantly at concentrations of 1 ng per ml and above whereas they enhance the migration of these cells at concentrations of 100 ng per ml and above. PGA2 and PGB2 are less potent as they inhibit spreading and adhesion only at a concentration of 1 μg per ml. At this concentration PGB2 enhances migration whereas PGA2 has no effect. PGF2α has no effect on the spreading, adhesion and migration of macrophages in the concentration range of 0.1 ng to 1,000 ng per ml. |
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