Recombinant human superoxide dismutase can attenuate ischemic neuronal damage in gerbils. |
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| Authors: | M Tagaya M Matsumoto K Kitagawa M Niinobe T Ohtsuki R Hata S Ogawa N Handa K Mikoshiba T Kamada |
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| Institution: | First Department of Internal Medicine, Osaka University Medical School, Japan. |
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| Abstract: | The effects of recombinant human superoxide dismutase (r-hSOD) on ischemic neuronal injury were examined. Cerebral ischemia was produced in Mongolian gerbils by occluding bilateral common carotid arteries for 5 min. Preischemic treatment with r-hSOD clearly reduced hippocampal neuronal damages while postischemic treatment did not. This result suggests that oxygen free radicals play an important role in selective vulnerability to ischemia and r-hSOD has a potential clinical usefulness against cerebral ischemia. |
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