| Abstract: | Some new 7-substituted-phenyl-3,4,8,9-tetrahydro-2H-pyridazino1,6-a]1,3,5]triazin-2-imine/one/thione derivatives were synthesized by a sequence of reactions starting from appropriate aryl hydrocarbons. The final compounds were screened for antihypertensive activities by non-invasive method using Tail Cuff method. All the test compounds showed significant antihypertensive activity; 7-(biphenyl-4-yl)-3,4,8,9-tetrahydro-2H-pyridazino1,6-a]1,3,5]triazin-2-imine (4p) exhibited antihypertensive activity more than the reference standard drugs. |
