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The Potential Use of Mechanism-Based Enzyme Inactivators in Medicine |
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| Abstract: | AbstractA new three dimensional representation of enzyme inhibition, applied to Lineweaver-Burk, Hanes and Eadie-Hofstee plots is presented. This type of representation has advantages for enzyme inhibition diagnosis, showing graphic characteristics that pass unnoticed in linear plots. |
| Keywords: | Mechanism-based enzyme inactivator alanine racemase S-adenosylhomocysteine hydrolase D-amino acid aminotransferase γ-aminobutyric acid aminotransferase arginine decarboxylase aromatase L-aromatic amino acid decarboxylase dihydrofolate reductase dihydroorotate dehydrogenase DNA polymerase I dopamine β-hydroxylase histidine decarboxylase β-lactamase monoamine oxidase ornithine decarboxylase serine proteases testosterone 5α-reductase thymidylate synthetase xanthine oxidase |