|
|||||
|
|
Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants |
|
| Authors: | Cena Clara Boschi Donatella Tron Gian Cesare Chegaev Kostantin Lazzarato Loretta Di Stilo Antonella Aragno Manuela Fruttero Roberta Gasco Alberto |
| Affiliation: | aDipartimento di Scienza e Tecnologia del Farmaco, Via P. Giuria 9, I-10125 Torino, Italy bDipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Via Bovio 6, I-28100 Novara, Italy cDipartimento di Medicina e Oncologia Sperimentale, C.so Raffaello 30, I-10125 Torino, Italy |
| Abstract: | A new class of NO-donor phenol derivatives is described. The products were obtained by joining appropriate phenols with either nitrooxy or 3-phenylsulfonylfuroxan-4-yloxy moieties. All the compounds proved to inhibit the ferrous salt/ascorbate induced lipidic peroxidation of membrane lipids of rat hepatocytes. They were also capable of dilating rat aorta strips precontracted with phenylephrine. |
| Keywords: | Phenol antioxidants Nitric oxide NO donors NO-donor phenol antioxidants |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |