Effect of insulin and cortisol on oxidation of (1-14C)glucose, (6-14C)glucose, (1-14C)palmitate and (1-14C)leucine in the tissues of swine during the neonatal period

The intensity of 1-14C]glucose, 6-14C]glucose, 1-14C]palmitate and 1-14C]leucine oxidation and the effect of insulin and hydrocortisone on this process were studied in the brain, duodenum mucosa, liver and skeletal muscle of 1- and 5-day old piglets in vitro. Most of the studied substrates are oxidized in the tissues of 5-day piglets more intensively. Insulin stimulates oxidation of 1-14C]glucose, 6-14C]glucose and 1-14C]leucine in the brain and duodenum mucosa in 1- and 5-day old piglets, while in the liver and skeletal muscle--only in 5-day old piglets. Hydrocortisone administration enhances oxidation of 1-14C]leucine in most of the studied tissues in 1-day piglets and oxidation of 1-14C]glucose and 6-14C]glucose--in 5-day piglets. Both hormones produce no essential influence on the intensity of 1-14C]palmitate oxidation in the studied tissues of piglets or somewhat weaken it.