Vanillin as a modulator agent in SMART test: inhibition in the steps that precede N-methyl-N-nitrosourea-, N-ethyl-N-nitrosourea-, ethylmethanesulphonate- and bleomycin-genotoxicity |
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Authors: | Sinigaglia Marialva Lehmann Maurício Baumgardt Paula do Amaral Viviane Souza Dihl Rafael Rodrigues Reguly Maria Luíza de Andrade Heloísa Helena Rodrigues |
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Institution: | Laboratório de Mutagênese, Departamento de Genética, Universidade Federal do Rio Grande do Sul, CP 15053, 91501-970 Porto Alegre, RS, Brazil. |
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Abstract: | Vanillin (VA), the world's major flavoring compound used in food industry and confectionery products - that has antimutagenic and anticarcinogenic activity against a variety of mutagenic/carcinogenic agents - was tested for the interval between the formation of premutational lesion and it is finalization as a DNA lesion. The overall findings using co-treatment protocols in SMART test suggest that VA can lead to a significant protection against the general genotoxicity of ethylmethanesulphonate (EMS), N-ethyl-N-nitrosourea (ENU), N-methyl-N-nitrosourea (MNU) and bleomycin sulphate (BLEO). Considering MNU, ENU and EMS the desmutagenic activity observed could result from VA-stimulation of detoxification, via induction of glutathione S-transferase. However, the protector effect related to BLEO could be attributed to its powerful scavenger ability, which has the potential to prevent oxidative damage induced by BLEO. |
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