N-Substituted acetamidines and 2-methylimidazole derivatives as selective inhibitors of neuronal nitric oxide synthase |
| |
Authors: | Maccallini Cristina Patruno Antonia Lannutti Fabio Ammazzalorso Alessandra De Filippis Barbara Fantacuzzi Marialuigia Franceschelli Sara Giampietro Letizia Masella Simona Felaco Mario Re Nazzareno Amoroso Rosa |
| |
Institution: | Dipartimento di Scienze del Farmaco, Università G. d'Annunzio, via dei Vestini, 66100 Chieti, Italy. |
| |
Abstract: | A series of N-substituted acetamidines and 2-methylimidazole derivatives structurally related to W1400 were synthesized and evaluated as Nitric Oxide Synthase (NOS) inhibitors. Analogs with sterically hindering isopropyl and phenyl substituents on the benzylic carbon connecting the aromatic core of W1400 to the acetamidine nitrogen, showed good inhibitory potency for nNOS (IC(50)=0.2 and 0.3 μM) and selectivity over eNOS (500 and 1166) and to a lesser extent over iNOS (50 and 100). A molecular modeling study allowed to shed light on the effects of the structural modifications on the selectivity of the designed inhibitors toward the different NOS isoforms. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |