SAMPI: Protein Identification with Mass Spectra Alignments |
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| Authors: | Hans-Michael Kaltenbach Andreas Wilke Sebastian Böcker |
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| Institution: | 1.AG Genominformatik, Technische Fakult?t,Universit?t Bielefeld,Bielefeld,Germany;2.Computation Institute,University of Chicago,Chicago,USA;3.Lehrstuhl für Bioinformatik,Friedrich-Schiller-Universit?t Jena,Jena,Germany |
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| Abstract: | Background Mass spectrometry based peptide mass fingerprints (PMFs) offer a fast, efficient, and robust method for protein identification.
A protein is digested (usually by trypsin) and its mass spectrum is compared to simulated spectra for protein sequences in
a database. However, existing tools for analyzing PMFs often suffer from missing or heuristic analysis of the significance
of search results and insufficient handling of missing and additional peaks. |
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