New polyhydroxylated sterols stylisterols A-C and a novel 5,19-cyclosterol hatomasterol from the Okinawan marine sponge Stylissa sp |
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| Authors: | Mitome Hidemichi Shirato Nao Hoshino Ayako Miyaoka Hiroaki Yamada Yasuji Van Soest Rob W M |
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| Institution: | School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan. |
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| Abstract: | New polyhydroxylated sterols, stylisterol A-C (1-3), and a novel 5,19-cyclosterol, hatomasterol (4) were isolated from the Okinawan sponge Stylissa sp. Structural determinations of these compounds were made by spectroscopic analysis and chemical conversion. Assessment of cytotoxicity toward HeLa cells was also determined. |
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| Keywords: | Sterols Sponge Stylissa sp Marine metabolites Polyhydroxylated sterols 5 19-Cyclosterol |
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