TRPM channels are required for rhythmicity in the ultradian defecation rhythm of <Emphasis Type="Italic">C. elegans</Emphasis> |
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Authors: | Claire SM Kwan Rafael P Vázquez-Manrique Sung Ly Kshamata Goyal Howard A Baylis |
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Institution: | (1) Department of Zoology, University of Cambridge, Downing Street, Cambridge, CB2 3EJ, UK |
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Abstract: | Background Ultradian rhythms, rhythms with a period of less than 24 hours, are a widespread and fundamental aspect of life. The mechanisms
underlying the control of such rhythms remain only partially understood. Defecation in C. elegans is a very tightly controlled rhythmic process. Underlying the defecation motor programme is an oscillator which functions
in the intestinal cells of the animal. This mechanism includes periodic calcium release and subsequent intercellular calcium
waves which in turn regulate the muscle contractions that make up the defecation motor programme. Here we investigate the
role of TRPM cation channels in this process. |
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Keywords: | |
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