Rapid acid treatment of Escherichia coli: transcriptomic response and recovery |
| |
| Authors: | Geetha Kannan Jessica C Wilks Devon M Fitzgerald Brian D Jones Sandra S BonDurant Joan L Slonczewski |
| |
| Affiliation: | (1) Department of Biology, Kenyon College, 43022 Gambier, OH, USA;(2) Department of Mathematics, Kenyon College, 43022 Gambier, OH, USA;(3) Gene Expression Center, University of Wisconsin, 53706 Madison, WI, USA |
| |
| Abstract: | Background Many E. coli genes show pH-dependent expression during logarithmic growth in acid (pH 5–6) or in base (pH 8–9). The effect of rapid pH change, however, has rarely been tested. Rapid acid treatment could distinguish between genes responding to external pH, and genes responding to cytoplasmic acidification, which occurs transiently following rapid external acidification. It could reveal previously unknown acid-stress genes whose effects are transient, as well as show which acid-stress genes have a delayed response. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
